One of the most common complaints isn't acne or wrinkles—it's dry, dehydrated skin. People taking GLP-1 medications often describe their skin as feeling tight after cleansing, looking dull despite moisturizing, becoming more sensitive to products they've used for years, or developing flaky patches that never seemed to exist before. Others notice that fine lines appear more noticeable, makeup doesn't apply as smoothly, or their complexion simply looks tired.