Why Microneedling with PDRN Outperforms PRP and PRF for Skin Rejuvenation
- audreydevallois
- Oct 7
- 3 min read
In the world of regenerative skincare, microneedling has become one of the most popular treatments for improving skin texture, reducing fine lines, and repairing acne scars. Two of the most commonly discussed enhancements to microneedling are PRP/PRF (Platelet-Rich Plasma/Platelet-Rich Fibrin) and PDRN (Polydeoxyribonucleotide). Both aim to accelerate healing and maximize results, but there are significant differences in how they work and the outcomes patients can expect.
At The Parlour, we prefer microneedling with PDRN over PRP/PRF for several key reasons, including consistency, regenerative potential, and reduced variability related to the patient’s health.
What is Microneedling with PDRN?
Microneedling with PDRN combines the mechanical stimulation of microneedling with the regenerative benefits of polydeoxyribonucleotide, a naturally occurring DNA fragment derived from salmon. PDRN works at a cellular level to:Stimulate fibroblasts to increase collagen (types I and III) and elastin productionPromote angiogenesis (formation of new capillaries) to improve skin oxygenationEnhance skin hydration and elasticity through improved extracellular matrix supportUnlike PRP/PRF, which relies on your blood platelets to release growth factors, PDRN provides a ready-to-use regenerative molecule, ensuring consistent efficacy across all patients.
How PRP and PRF Microneedling Works
PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) require the patient’s own blood to extract growth factors for skin regeneration:
Blood Draw: A small amount of the patient’s blood is drawn, typically 10–60 mL depending on the protocol.
Centrifugation: The blood is spun in a centrifuge to separate plasma rich in platelets (PRP) or fibrin (PRF) from red and white blood cells.
Activation and Application: The concentrated platelets are activated, releasing growth factors and cytokines, and then applied to the skin during or after microneedling.
Key Limitation: The success of PRP/PRF depends heavily on the patient’s baseline platelet count and health. Factors such as age, nutrition, medications, and medical conditions can affect platelet quality and concentration, which directly impacts the results.
Why PDRN Offers More Consistent and Reliable Results
Independence from Patient Platelet Health
PRP results can vary from patient to patient. Someone with a lower platelet count may see minimal improvements, while a healthy patient may experience excellent results.
PDRN bypasses this variability since it does not rely on the patient’s blood.
Faster Cellular Regeneration
PDRN directly stimulates fibroblasts and endothelial cells, enhancing collagen synthesis and angiogenesis more predictably than PRP.
Broader Applications
Safe for patients who cannot undergo PRP due to blood disorders, anemia, or certain medications.
Reduced Risk of Complications
Since PDRN is pre-formulated and sterile, there’s less risk of contamination compared to handling blood-derived PRP.
Ideal Candidates for PDRN Microneedling
PDRN microneedling is ideal for:
Patients seeking anti-aging benefits (fine lines, wrinkles, and skin laxity)
Individuals with acne scars, post-inflammatory hyperpigmentation, or uneven texture
Patients with sensitive skin or conditions where PRP may be less effective
Anyone who desires predictable results without relying on their own platelet health
What to Expect During the Procedure
Consultation: Evaluate skin type, concerns, and medical history
Preparation: Cleanse skin, apply numbing cream
Microneedling: Controlled micro-injuries stimulate natural healing
PDRN Application: PDRN solution is applied to maximize regenerative effects
Post-Care: Redness is expected for 24–48 hours; products and sunscreen are recommended
How Many Sessions Are Needed?
Typical course: 3–6 sessions spaced 3–4 weeks apart
Maintenance: 1–2 treatments per year for ongoing collagen support
FAQs
“Does my platelet health affect PRP results?” → Yes, patients with low platelet counts may see reduced efficacy with PRP.
“Is PDRN better than PRP for aging skin?” → PDRN provides more consistent fibroblast stimulation and collagen production, leading to predictable rejuvenation.
“How many PDRN microneedling sessions are needed for acne scars?” → Generally 4–6 sessions, depending on severity.
Book Your PDRN Microneedling Consultation Today!
Experience predictable, regenerative results that improve skin texture, reduce fine lines, and repair acne scars. Book online or call our Pinecrest medical spa today!
