Why Microneedling + PDRN Is the Next-Level Way to Rejuvenate Your Skin
- audreydevallois
- Nov 12
- 6 min read
At The Parlour we’re always striving to bring you the most advanced and effective skin-rejuvenation protocols — combining proven science with beautifully curated post-care. One of the most exciting advances in aesthetic treatment is the pairing of microneedling with Polydeoxyribonucleotide (PDRN). In this blog, we’ll walk you through:
what microneedling does for your skin
what PDRN is and how it enhances results
why combining them elevates outcomes
how to care for your skin afterward
how alternating with laser treatments (like PureYAG laser treatment) and facials can maintain and amplify your results
By the end, you’ll understand not just why this treatment works, but how to get the most from it — from your session at The Parlour to your at-home routine.
What Microneedling Can Do for Your Skin
Microneedling (sometimes referred to as “collagen-induction therapy”) uses fine medical-grade needles to create controlled micro-injuries in the skin. This triggers your body’s natural wound-healing cascade: fibroblasts are activated, collagen and elastin production increases, and skin texture, tone, and firmness improve.
Here’s a summary of the key benefits:
Improved skin texture & tone: The micro-channels created allow for smoothing of fine lines, reduction of pore size and an overall more even surface.
Reduced appearance of fine lines and wrinkles: As new collagen and elastin form, skin becomes firmer and lines soften.
Enhanced skin elasticity and resilience: The structural support beneath the surface is strengthened, so skin “bounces back” better.
Improved results for scars, hyperpigmentation & uneven tone: The micro-injuries prompt regeneration of healthier skin cells, and when paired with something like PDRN (more on that shortly) it can help fade acne scars and discoloration.
Minimal downtime: Compared to deep chemical peels or surgical options, microneedling offers a strong result with relatively faster recovery.
In short: microneedling is a powerful tool for rejuvenation, especially when you want effective change without extensive downtime. Learn more about our microneedling services here.
What Is PDRN (Polydeoxyribonucleotide) — And Why It Matters
Now for the “secret sauce” that elevates microneedling: PDRN.
PDRN stands for polydeoxyribonucleotide, a purified mixture of DNA fragments most commonly derived from salmon or trout sperm cells (yes, that’s the surprising origin).
It is extracted via a controlled purification process so that proteins and peptides (which might cause immune reactions) are removed — leaving behind deoxyribonucleotides that are highly biocompatible.
Mechanisms of action:
It engages the adenosine A₂A receptor pathway, which helps regulate inflammation and tissue repair.
It supplies nucleotides and nucleosides that support the “salvage pathway” of DNA repair and cell regeneration.
It stimulates fibroblasts (cells that produce collagen/elastin), improves microcirculation, enhances angiogenesis (new blood vessel formation) and reduces melanogenesis (pigment formation).
In simpler terms: PDRN tells your skin, “Hey — time to repair! Build new structure! Heal faster!” From a skincare perspective, this means better texture, improved elasticity, less redness, and stronger barrier function.
Clinical and in-office studies show that PDRN supports wound healing, is safe and well-tolerated, and enhances results when used in conjunction with procedures.
Why Microneedling + PDRN Is a Power Combo
When you pair microneedling with PDRN you get a synergy that neither treatment alone can achieve. Here’s how it works:
Microneedling opens the door – the micro-channels created by the needles allow deeper penetration of active ingredients and stimulate healing cascades.
PDRN moves in – the newly created micro-injuries allow the PDRN molecule to more directly access the dermis, maximizing its regenerative signaling.
Accelerated healing and enhanced collagen/elastin production – together you get more rapid recovery, stronger structural repair, improved tone/texture, and better overall skin quality.
Better results for scars, pigment and resilience – this combo is especially suited for individuals looking to tone down acne scars, uneven tone, pigmentation, and improve overall skin “health”, not just surface smoothing.
At The Parlour, this means we can offer a more advanced microneedling experience — one that supports deeper regeneration, faster recovery and longer-lasting benefits.
After-Care: Maximizing Your Results with the Right Post-Procedure Kit
After microneedling, post-treatment skincare is absolutely critical. Your skin is in a heightened state of repair and you want to support it — not hinder it. That’s why we recommend our very own Hazy Halo Post-Procedure Kit, specially designed to enhance your results and safeguard your outcome.
Here’s how to use it, and why each component matters:
Gentle Papaya Enzyme Cleanser
Use morning and evening (starting the next day unless otherwise advised). This gentle enzyme cleanser helps remove debris and dead skin without harsh abrasion, so you’re supporting detox and renewal without disrupting the repair process.
Dew Drop Hyaluronic Acid Serum
Day and night, apply the Dew Drop — a fractionated hyaluronic acid hydrating serum that deeply moisturizes skin and helps lock in moisture. Hydration is key for optimal collagen production and overall outcome.
Recovery Moisturizer
Twice daily, apply the recovery moisturizer to calm, hydrate and reinforce the skin barrier. This step helps reduce redness, supports healing, and keeps your skin comfortable as collagen rebuilding occurs.
Sheer Shield SPF
After microneedling your skin is more vulnerable to sun damage and pigment shifts. Broad-spectrum UV protection is non-negotiable. We recommend applying Sheer Shield SPF every morning (and reapplying midday if exposed). Learn more about our SPF options here.
Why this kit matters:
It’s formulated specifically for post-procedural skin: gentle, non-irritating, barrier-supporting.
It complements the cellular repair triggered by microneedling + PDRN, keeping your skin in a regeneration-friendly environment.
By using the right after-care you reduce risk of complications (like pigment, prolonged redness or uneven texture) and support the best possible outcome of your treatment.
At The Parlour, our staff will guide you on timing (when to start each product, how often to apply) and customize based on your skin type, treatment intensity and desired goals.
Alternating Treatments: Why Laser (PureYAG) + Facials Make Great Add-Ons
While microneedling + PDRN is a cornerstone treatment for many clients, smart treatment plans often include alternating modalities for maintenance, enhancement and overall skin health. Two excellent options:
PureYAG laser treatment (or comparable YAG/laser skin-resurfacing treatments)
Laser treatments work by delivering targeted energy (heat/light) into skin layers, stimulating collagen, tightening tissue, reducing pigment and improving tone. Alternating a laser session with microneedling helps address different layers, textures and concerns — and keeps your skin consistently advancing rather than plateauing.
Medical-grade Facials
While less intense than microneedling or lasers, customized facials maintain skin health, clear debris, improve circulation, provide gentle exfoliation and hydration support. They’re perfect for between-treatment “maintenance” and help prolong the benefits of your more intensive sessions.
Why alternating matters:
Each modality has unique strengths; combining or alternating them prevents overlap and maximizes benefit.
You give your skin time to recover from the microneedling + PDRN while still engaging in rejuvenation via the other treatments.
It keeps your plan flexible: for example, you might schedule microneedling + PDRN every 2-3 months, a laser session 2-4 weeks later, and facials monthly or bi-monthly in between.
At The Parlour we’ll build your personalized roadmap: we’ll consider your skin’s starting point, downtime preferences, goals (texture, tone, firmness, pigmentation) and schedule accordingly. Explore our laser facial treatment options here.
What to Expect: Timeline, Results & Candidacy
Who is a good candidate for microneedling?
Most healthy adults looking to improve texture, tone, firmness, fine lines, pores or mild scars can benefit from microneedling + PDRN. That said, certain conditions (active infection, uncontrolled acne, recent isotretinoin use, certain skin diseases) require medical clearance. Our staff will evaluate your skin history, pigmentation risk, allergy profile (note: if you have a fish/shellfish allergy caution with PDRN derived from salmon/trout) and overall expectations.
What happens during a microneedling treatment?
The skin is cleansed, numbed if needed.
Microneedling is performed to create controlled micro-injuries.
Immediately (or very soon after) the PDRN serum (or injectable/mesotherapy version) is applied, facilitating absorption into the deeper layers.
Post-treatment instructions are given (including use of the Hazy Halo kit, avoiding certain actives, sun protection, etc.).
Typical timeline & results:
Immediately after: you may experience some redness, slight swelling, maybe mild sensitivity (this is normal).
Days 2-4: You’ll see initial glow, hydration, maybe some mild peeling or shedding depending on depth of needles.
Weeks 2-4: Collagen production kicks in; you’ll begin to see smoother texture, more even tone, tighter skin.
Months 2-3: The full effect starts to emerge — firmer, revitalised skin, less visible lines/pores, improved tone. Many clients continue improving up to 6 months depending on their treatment series and maintenance plan.
Maintenance & frequency:
For many clients, we recommend a series of 2-4 treatments spaced 4-6 weeks apart (depending on skin condition and goals). After the initial series, a maintenance session every 4-6 months helps keep the benefits. Alternating with laser and facials (as described) ensures your skin continues to progress.
Final Thoughts & Next Steps
If you’re ready to elevate your skin-regeneration strategy, the combination of microneedling plus PDRN is one of the smartest moves you can make — especially when paired with the right post-care and a complementary treatment plan. At The Parlour, we don’t just deliver the treatment and send you home — we support you through every step, including offering our custom Hazy Halo Post-Procedure Kit (Gentle Papaya Enzyme Cleanser, Sheer Shield SPF, Recovery Moisturizer and Dew Drop) to extend your results, reduce downtime and maximize your investment.
Ready to begin?
Schedule a consultation with our expert team — we’ll assess your skin, outline your customised plan (microneedling + PDRN, maintenance laser/facial support, timeline, pricing), and set you up with the tools you need for glowing, resilient, youthful-looking skin.
Thank you for trusting us with your skin journey. We can’t wait to see your transformation!